The utility of apparent diffusion coefficient values in the risk stratification of prostate cancer using a 1.5T magnetic resonance imaging without endorectal coil

  • João Lopes Dias Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • João Magalhães Pina Department of Urology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Nuno Vasco Costa Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Sandra Carmo Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Cecília Leal Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Tiago Bilhim Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Rui Mateus Marques Department of Radiology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Luís Campos Pinheiro Department of Urology, Hospital de São José, Centro Hospitalar de Lisboa Central, Lisboa, Portugal

Abstract

Purpose
To evaluate the relationship between mean apparent diffusion coefficient (ADC) and post-surgical Gleason scores. To determine the diagnostic accuracy of multiparametric magnetic resonance imaging (mp-MRI) on a 1.5T magnet in distinguishing low, intermediate and high-grade prostate tumors.
Material and methods
This is a retrospective institutional-review-board-approved, single-center study including 30 patients (median age, 60 years) who underwent mp-MRI before prostatectomy for prostate cancer. Using histological reports for guidance, the tumors were localized in ADC maps, and mean ADCs were measured and examined for correlation with Gleason scores. 2 patients had 2 measurable foci, so a total of 32 tumors were studied. The diagnostic accuracy of the mean ADC was assessed by using the area under the receiver operating characteristic curve (ROC).
Results
In the differentiation of tumors with a Gleason score of 6 from those with a Gleason score of at least 7, mean ADC yielded an AUC of 0.76 (95% confidence interval: 0.59, 0.93). In the differentiation of tumors with Gleason scores of 6 or 7 from those with a Gleason score of at least 8, mean ADC yielded an AUC of 0.94 (95% confidence interval: 0.86, 1.00).
Conclusion
Mean ADC values may allow a correct assessment of the patient risk using a 1.5T magnet without ERC.

References

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Published
2017-04-10
How to Cite
LOPES DIAS, João et al. The utility of apparent diffusion coefficient values in the risk stratification of prostate cancer using a 1.5T magnetic resonance imaging without endorectal coil. Acta Urológica Portuguesa, [S.l.], v. 33, n. 3, p. 81-86, apr. 2017. ISSN 2387-0419. Available at: <http://www.actaurologicaportuguesa.com/index.php/aup/article/view/33>. Date accessed: 24 june 2017.
Section
Original Article