Tracheobronchial Uptake on [68Ga]Ga-PSMA-11 PET/CT: An Incidental Finding

Inês Cardoso Ferreira; Olívia Leal Silva; João Ramos; Joaquim Geraldes Santos

doi:10.24915/aup.260

Authors

Inês Cardoso Ferreira Centro de Responsabilidade Integrado de Medicina Nuclear – Unidade Local de Saúde de Almada - Seixal, Almada, Portugal https://orcid.org/0009-0005-3391-5703
Olívia Leal Silva Centro de Responsabilidade Integrado de Medicina Nuclear – Unidade Local de Saúde de Almada - Seixal, Almada, Portugal
João Ramos Serviço de Urologia – Unidade Local de Saúde do Arco Ribeirinho, Barreiro, Portugal
Joaquim Geraldes Santos Centro de Responsabilidade Integrado de Medicina Nuclear – Unidade Local de Saúde de Almada - Seixal, Almada, Portugal

DOI:

https://doi.org/10.24915/aup.260

Keywords:

Gallium Radioisotopes, Positron-Emission Tomography Computed Tomography, Prostatic Neoplasms, Incidental Findings

Abstract

Prostate-specific membrane antigen (PSMA) PET/CT is widely used in prostate cancer evaluation but may show uptake in non-prostatic tissues. We report the case of a 69-year-old man with severe COPD and multiple comorbidities undergoing [68Ga]Ga-PSMA-11 PET/CT for rising PSA. Imaging revealed heterogeneous prostatic uptake and moderate diffuse tracheobronchial uptake, more intense on the left, along with cervicothoracic ganglia uptake. This case highlights tracheobronchial uptake as a potential pitfall, possibly related to physiologic PSMA expression, and underscores the need for awareness in patients with underlying pulmonary disease.

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References

Spinelli V, Finessi M, Colletti PM. Tracheo-bronchial tree uptake in PET/CT 18F-PSMA ([18F]DCFP].a variant of physiological distribution. Rev Esp Med Nucl Imagen Mol. 2022;45:195. doi:10.1016/j.renmie.2022.09.008

Bronte Viedma A, Martinez de la Haza AL, Serrano Cabeza JM, Campo Ezquibela A, Rodriguez-Fraile M. Asthma as an inflammatory reason of tracheobronchial PSMA uptake. Clin Nucl Med. 2023;48:e494–5. doi:10.1097/RLU.000000000004784

Aksu A, Durmus N, Altay C. Tracheitis diagnosed with 68Ga-PSMA PET/CT in a patient with COVID-19. Clin Nucl Med. 2022;47:e656–7. doi:10.1097/RLU.000000000004288

Osman MM, Subramaniam RM, Rowe SP, Hicks RJ, Perry E, Hofman MS. 18F-DCFP_.PSMA PET/CT tracheobronchial uptake in patients with prostate cancer: incidence and etiology. J Nucl Med. 2024;65:1383–6. doi:10.2967/jnumed.124.267772