Focal therapies for the treatment of localized prostate cancer: The role of irreversible electroporation – Present or future?


  • Pedro Conceição Fernandes Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal
  • Bruno Jorge Pereira Serviço de Urologia, Hospital Pêro da Covilhã, Centro Hospitalar Cova da Beira, EPE, Covilhã, Portugal



Prostate cancer, Focal therapy, Focal treatment, Electroporation


In the PSA era, the incidence of localized prostate cancer has been increasing. This reality requires new therapeutic strategies, in order to give an answer to patients, in whom active surveillance may be indicate but desire more interventionist strategy with minimal side effects and without compromising cancer control. In these cases, focal therapies that include irreversible electroporation may be effective alternative strategies. The irreversible electroporation is an emergent approach on focal treatment of localized PCa. The nonthermal mechanism that preserves the tissue architecture without damaging tissue structures, such as vessels and nerves within the target region, is the main advantage comparatively to other techniques used in focal treatment. The number of clinical studies is reduced and the results still immature.


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